@article {1658009,
	title = {Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis},
	journal = {Front Neurosci},
	volume = {15},
	year = {2021},
	note = {1662-453xSumner, Jennifer AMaihofer, Adam XMichopoulos, VasilikiRothbaum, Alex OAlmli, Lynn MAndreassen, Ole AAshley-Koch, Allison EBaker, Dewleen GBeckham, Jean CBradley, BekhBreen, GeromeColeman, Jonathan R IDale, Anders MDennis, Michelle FFeeny, Norah CFranz, Carol EGarrett, Melanie EGillespie, Charles FGuffanti, GuiaHauser, Michael AHemmings, Sian M JJovanovic, TanjaKimbrel, Nathan AKremen, William SLawford, Bruce RLogue, Mark WLori, AdrianaLyons, Michael JMaples-Keller, JessicaMavissakalian, Matig RMcGlinchey, Regina EMehta, DivyaMellor, RebeccaMilberg, WilliamMiller, Mark WMorris, Charles PhillipPanizzon, Matthew SRessler, Kerry JRisbrough, Victoria BRothbaum, Barbara ORoy-Byrne, PeterSeedat, SorayaSmith, Alicia KStevens, Jennifer Svan den Heuvel, Leigh LuellaVoisey, JoanneYoung, Ross McDZoellner, Lori ANievergelt, Caroline MWolf, Erika JK12 HD085850/HD/NICHD NIH HHS/United StatesR01 AG064955/AG/NIA NIH HHS/United StatesR01 MH062482/MH/NIMH NIH HHS/United StatesUL1 TR002378/TR/NCATS NIH HHS/United StatesI01 CX001276/CX/CSRD VA/United StatesR01 MH106595/MH/NIMH NIH HHS/United StatesK01 HL130650/HL/NHLBI NIH HHS/United StatesR21 MH102834/MH/NIMH NIH HHS/United StatesR01 AG022381/AG/NIA NIH HHS/United StatesR01 AG050595/AG/NIA NIH HHS/United StatesJournal ArticleFront Neurosci. 2021 Jun 23;15:678503. doi: 10.3389/fnins.2021.678503. eCollection 2021.},
	pages = {678503},
	edition = {2021/07/13},
	abstract = {Growing research suggests that posttraumatic stress disorder (PTSD) may be a risk factor for poor cardiovascular health, and yet our understanding of who might be at greatest risk of adverse cardiovascular outcomes after trauma is limited. In this study, we conducted the first examination of the individual and synergistic contributions of PTSD symptoms and blood pressure genetics to continuous blood pressure levels. We harnessed the power of the Psychiatric Genomics Consortium-PTSD Physical Health Working Group and investigated these associations across 11 studies of 72,224 trauma-exposed individuals of European (n = 70,870) and African (n = 1,354) ancestry. Genetic contributions to blood pressure were modeled via polygenic scores (PGS) for systolic blood pressure (SBP) and diastolic blood pressure (DBP) that were derived from a prior trans-ethnic blood pressure genome-wide association study (GWAS). Results of trans-ethnic meta-analyses revealed significant main effects of the PGS on blood pressure levels [SBP: β = 2.83, standard error (SE) = 0.06, p < 1E-20; DBP: β = 1.32, SE = 0.04, p < 1E-20]. Significant main effects of PTSD symptoms were also detected for SBP and DBP in trans-ethnic meta-analyses, though there was significant heterogeneity in these results. When including data from the largest contributing study - United Kingdom Biobank - PTSD symptoms were negatively associated with SBP levels (β = -1.46, SE = 0.44, p = 9.8E-4) and positively associated with DBP levels (β = 0.70, SE = 0.26, p = 8.1E-3). However, when excluding the United Kingdom Biobank cohort in trans-ethnic meta-analyses, there was a nominally significant positive association between PTSD symptoms and SBP levels (β = 2.81, SE = 1.13, p = 0.01); no significant association was observed for DBP (β = 0.43, SE = 0.78, p = 0.58). Blood pressure PGS did not significantly moderate the associations between PTSD symptoms and blood pressure levels in meta-analyses. Additional research is needed to better understand the extent to which PTSD is associated with high blood pressure and how genetic as well as contextual factors may play a role in influencing cardiovascular risk.},
	keywords = {Blood Pressure, commercial or financial relationships that could be construed as a potential, conflict of interest., Genetics, meta-analysis, Posttraumatic stress disorder, trans-ethnic},
	isbn = {1662-4548 (Print)1662-453x},
	author = {Sumner, J. A. and Maihofer, A. X. and Michopoulos, V. and Rothbaum, A. O. and Almli, L. M. and Andreassen, O. A. and Ashley-Koch, A. E. and Baker, D. G. and Beckham, J. C. and Bradley, B. and Breen, G. and Coleman, J. R. I. and Dale, A. M. and Dennis, M. F. and Feeny, N. C. and Franz, C. E. and Garrett, M. E. and Gillespie, C. F. and Guffanti, G. and Hauser, M. A. and Hemmings, S. M. J. and Jovanovic, T. and Kimbrel, N. A. and Kremen, W. S. and Lawford, B. R. and Logue, M.W. and Lori, A. and Lyons, M. J. and Maples-Keller, J. and Mavissakalian, M. R. and McGlinchey, R.E. and Mehta, D. and Mellor, R. and Milberg, W. and Miller, M. W. and Morris, C. P. and Panizzon, M. S. and Ressler, K. J. and Risbrough, V. B. and Rothbaum, B. O. and Roy-Byrne, P. and Seedat, S. and Smith, A. K. and Stevens, J. S. and van den Heuvel, L. L. and Voisey, J. and Young, R. M. and Zoellner, L. A. and Nievergelt, C. M. and Wolf, E.J.}
}
