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Mild Cognitive Impairment is Associated With White Matter Integrity Changes in Late-Myelinating Regions Within the Corpus Callosum

Citation:

Stricker, N. H., Salat, D. H., Kuhn, T. P., Foley, J. M., Price, J. S., Westlye, L. T., Esterman, M. S., et al. (2016). Mild Cognitive Impairment is Associated With White Matter Integrity Changes in Late-Myelinating Regions Within the Corpus Callosum. Am J Alzheimers Dis Other Demen , 31, 68-75.

Date Published:

Feb

Abstract:

Degenerative brain changes in Alzheimer's disease may occur in reverse order of normal brain development based on the retrogenesis model. This study tested whether evidence of reverse myelination was observed in mild cognitive impairment (MCI) using a data-driven analytic approach based on life span developmental data. Whole-brain high-resolution diffusion tensor imaging scans were obtained for 31 patients with MCI and 79 demographically matched healthy older adults. Comparisons across corpus callosum (CC) regions of interest (ROIs) showed decreased fractional anisotropy (FA) in the body but not in the genu or splenium; early-, middle-, and late-myelinating ROIs restricted to the CC revealed decreased FA in late- but not early- or middle-myelinating ROIs. Voxelwise group differences revealed areas of lower FA in MCI, but whole-brain differences were equally distributed across early-, middle-, and late-myelinating regions. Overall, results within the CC support the retrogenesis model, although caution is needed when generalizing these results beyond the CC.

Notes:

1938-2731Stricker, Nikki HSalat, David HKuhn, Taylor PFoley, Jessica MPrice, Jenessa SWestlye, Lars TEsterman, Michael SMcGlinchey, Regina EMilberg, William PLeritz, Elizabeth CIK2 CX000706/CX/CSRD VA/United StatesR01 NS086882/NS/NINDS NIH HHS/United StatesP01AG004390/AG/NIA NIH HHS/United StatesK23NS062148/NS/NINDS NIH HHS/United StatesP60AG08812/AG/NIA NIH HHS/United StatesP01 AG004390/AG/NIA NIH HHS/United StatesK23 NS062148/NS/NINDS NIH HHS/United StatesP60 AG008812/AG/NIA NIH HHS/United States2T32DA015036/DA/NIDA NIH HHS/United StatesT32 DA015036/DA/NIDA NIH HHS/United StatesR01NR010827/NR/NINR NIH HHS/United StatesR01 NR010827/NR/NINR NIH HHS/United StatesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, Non-P.H.S.Am J Alzheimers Dis Other Demen. 2016 Feb;31(1):68-75. doi: 10.1177/1533317515578257. Epub 2015 Apr 22.